PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling.

PTK7/Otk interacts with Wnts and inhibits canonical Wnt signaling

Off-track takes Frizzled off the canonical path.

Like many other signalling pathways, the Wnt pathway is seen as part of a network that integrates extracellular information mediated by a variety of cell surface proteins to produce cell context-specific outputs. The identification of Frizzled as Wnt receptors (Bhanot et al, 1996) provided the essential link between extracellular Wnts and the intracellular components of Wnt signal transduction....

The PTK7-Related Transmembrane Proteins Off-track and Off-track 2 Are Co-receptors for Drosophila Wnt2 Required for Male Fertility

Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals. The cellular responses to Wnts are manifold and are determined by the respective Wnt ligand and its specific receptor complex in the plasma membrane. Wnt receptor complexes contain a member of the Frizzled family of serpentine receptors and a co-receptor, which commonly is a single-pass ...

Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.

The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog embryonic development. In this study, we report that PTK7 interacts with β-catenin in a yeast two-hybrid assay and mammalian cells. PTK7-deficient cells exhibit weakened β-catenin/T-cell factor transcriptional activity on Wnt3a stimulation. Fu...

Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development.

Using zebrafish, we have characterised the function of Protein tyrosine kinase 7 (Ptk7), a transmembrane pseudokinase implicated in Wnt signal transduction during embryonic development and in cancer. Ptk7 is a known regulator of mammalian neural tube closure and Xenopus convergent extension movement. However, conflicting reports have indicated both positive and negative roles for Ptk7 in canoni...